When counseling parents about genetic transmission of an X-linked disorder, which concept does the nurse keep in mind?
A) A male can pass an X-linked mutation to a son or a daughter.
B) A female can only pass an X-liked disorder to a son.
C) A male with a mutation in an X-linked gene will manifest the disease.
D) An X-linked disorder can be traced through the paternal lineage.
C) A male with a mutation in an X-linked gene will manifest the disease.
Explanation: A) A female can pass an X-linked mutation to a son or daughter, but only the son will manifest the severe form of the disease. A father cannot pass on the X-linked condition to his sons because a male inherits his X chromosome from his mother and the Y chromosome from his father. Therefore, in an X-linked condition, it is likely that only males will be affected, and the condition can be traced through the maternal lineage.
B) A female can pass an X-linked mutation to a son or daughter, but only the son will manifest the severe form of the disease. A father cannot pass on the X-linked condition to his sons because a male inherits his X chromosome from his mother and the Y chromosome from his father. Therefore, in an X-linked condition, it is likely that only males will be affected, and the condition can be traced through the maternal lineage.
C) A female can pass an X-linked mutation to a son or daughter, but only the son will manifest the severe form of the disease. A father cannot pass on the X-linked condition to his sons because a male inherits his X chromosome from his mother and the Y chromosome from his father. Therefore, in an X-linked condition, it is likely that only males will be affected, and the condition can be traced through the maternal lineage.
D) A female can pass an X-linked mutation to a son or daughter, but only the son will manifest the severe form of the disease. A father cannot pass on the X-linked condition to his sons because a male inherits his X chromosome from his mother and the Y chromosome from his father. Therefore, in an X-linked condition, it is likely that only males will be affected, and the condition can be traced through the maternal lineage.
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