Hearing loss can occur in animals. Some forms of hearing loss are iatrogenic. Name some nontopical medications that can cause ototoxicity

What will be an ideal response?


The FDA requires neither testing of inner ear function nor an examination of the inner ear structures when determining the safety of

a drug before it is released onto the market (for people or animals). Two areas damaged through ototoxicity are the hair cells in the inner ear and the vestibulocochlear nerve that runs from the inner ear to the brain. Some examples of drugs that cause ototoxicity include, but are not limited to, the following: Aspirin

Quinine (chloroquine, quinidine, quinine, and tonic water)

Loop diuretics (furosemide)

Aminoglycoside antibiotics (gentamicin, amikacin, dihydrostreptomycin, kanamycin, neomycin, tobramycin, and streptomycin) Antineoplastics (cisplatin, carboplatin) Chemicals (lead, mercury, toluene, and xylene)

Anatomy & Physiology

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