The results of a 44-year-old obese man's recent diagnostic workup have culminated in a new diagnosis of type 2 diabetes. Which of the following pathophysiologic processes underlies the client's new diagnosis?
A) Beta cell exhaustion due to long-standing insulin resistance
B) Destruction of beta cells that is not attributable to autoimmunity
C) T-lymphocyte–mediated hypersensitivity reactions
D) Actions of insulin autoantibodies (IAAs) and islet cell autoantibodies (ICAs)
Ans: A
Feedback:
Exhaustion of the beta cells arising from insulin resistance is characteristic of type 2 diabetes. Beta cell destruction in the absence of an autoimmune reaction is associated with type 1b diabetes, while autoimmune processes contribute to type 1a diabetes.
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