As adults, insulin signaling through its receptor kinase enables virtually every cell in our body to transport glucose across the plasma membrane into the cytosol. Use the following five terms to complete the sentences below
Terms (A-E) may be used once, more than once or not at all.
A. receptor binding
B. receptor activation
C. signal transduction and amplification
D. response
E. termination
Autophosphorlyation of transmembrane proteins caused by insulin association with those
proteins is an example of __________________.
_________________ occurs when the proteins that are phosphorylated after insulin
associates with the cell-surface protein become dephosphorylated.
The noncovalent association of insulin with specific proteins on the surface of a cell is an
example of ___________.
Activated proteins in the nucleus causing transcription (and eventually translation in the
cytosol) of proteins needed for cell division is an example of _________.
_______________ occurs when the insulin receptors phosphorylate each other causing
other proteins in the cytoplasm to bind to them, including a protein called insulin-receptor
substrate 1 (or IRS-1).
_______________ occurs when the phosphorylated cytosolic protein IRS-1 binds to other
cytosolic proteins to activate them, which in turn bind to others to activate them.
One consequence of IRS-1 stimulation is the exchange of GDP for GTP in Ras, which is an
example of _______________.
___________________ occurs when the GTP bound to Ras is hydrolyzed to GDP.
One consequence of IRS-1 stimulation is the uptake of glucose by the cell, which is an
example of ________________.
What will be an ideal response?
Autophosphorlyation of transmembrane proteins caused by insulin association with those
proteins is an example of B.
B occurs when the proteins that are phosphorylated after insulin associates with the cellsurface
protein become dephosphorylated.
The noncovalent association of insulin with specific proteins on the surface of a cell is an
example of A.
Activated proteins in the nucleus causing transcription (and eventually translation in the
cytosol) of proteins needed for cell division is an example of D.
C occurs when the insulin receptors phosphorylate each other causing other proteins in the
cytoplasm to bind to them, including a protein called insulin-receptor substrate 1 (or IRS-1).
C occurs when the phosphorylated cytosolic protein IRS-1 binds to other cytosolic proteins to
activate them, which in turn bind to others to activate them.
One consequence of IRS-1 stimulation is the exchange of GDP for GTP in Ras, which is an
example of C.
E occurs when the GTP bound to Ras is hydrolyzed to GDP.
One consequence of IRS-1 stimulation is the uptake of glucose by the cell, which is an
example of D.
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