Which of the following statements is correct concerning membrane-coding (MC) exons of immunoglobulin genes?
a. MC exons are located upstream (5?) of the constant-domain exons.
b. MC exons code for amino acids that anchor and stabilize the light chain to the membrane of B cells.
c. MC exons specify transmembrane hydrophobic amino acids that associate with the B-cell membrane.
d. MC exons are removed from primary RNA transcripts as a consequence of alternative mRNA splicing when secreted antibodies are produced by plasma cells.
e. Somatic hypermutation causes alteration in the coding sequence of MC exons.
C
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