What is the cause of myelodysplastic syndromes?
a. Decreased apoptosis
b. Are inherited disorders
c. Proliferation of mutated myeloid cells
d. Epstein-Barr virus
ANS: C
Proliferation of mutated myeloid stem cells is the cause for myelodysplastic syndromes. Apoptosis is increased in early myleodysplastic syndrome, giving rise to the cytopenia (or cytopenias); however, later, if the disease progresses and acute leukemia appears, then apoptosis decreases. They are not inherited, and no association exists with the Epstein-Barr virus.
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