When trying to educate a patient about the release of free radicals and the role they play in formation of atherosclerosis, which of the following statements is most accurate?
A)
The end result of oxidation is rupture of the plaque resulting in hemorrhage.
B)
Activated cells that release free radicals oxidize LDL, which is harmful to the lining of your blood vessels.
C)
Oxidized free radicals produce toxic metabolic waste that can kill liver cells.
D)
Activated cells roam in the vascular system looking for inflammatory cells to engulf.
Ans:
B
Feedback:
Activated macrophages release free radicals that oxidize LDL. Oxidized LDL is toxic to the endothelium, causing endothelial loss and exposure of the subendothelial tissue to the blood components. This leads to platelet adhesion and aggregation and fibrin deposition.
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