Which organ is the most responsible for the first-pass effect?
1. Bladder
2. Kidneys
3. Liver
4. Stomach
3
Rationale 1: The bladder is not the organ most responsible for the first-pass effect.
Rationale 2: The kidneys are not the organs most responsible for the first-pass effect.
Rationale 3: The first pass effect occurs in the liver.
Rationale 4: The stomach is not the organ most responsible for the first-pass effect.
Global Rationale: The first pass effect occurs in the liver.
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