A 40-year-old woman had tachycardia and bouts of sweating, and was found to have hyperthyroidism due to Graves' disease. Her blood contained antibodies to
A. Thyroid-stimulating hormone receptor
B. thyroglobulin
C. smooth antibodies
D. mitochondria
E. centromere
A
Patients with Graves' disease have antibodies to the receptor for the thyroid-stimulating hormone (TSH). These antibodies bind to thyroid follicular cells, stimulating them to produce thyroid hormones thyroxin (T4) and triiodothyronine (T3). Antibodies to thyroglobulin are found in Hashimoto's disease. Antibodies to smooth muscle cells are found in autoimmune hepatitis. Antibodies to mitochondria are found in primary biliary cirrhosis. Antibodies to centromere are found in scleroderma.
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Fill in the blank(s) with correct word
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