A nurse is providing preconception counseling to a healthy woman and her husband, who has hemophilia A. They are very concerned about passing the disorder on to their children. What should the nurse consider before addressing this concern?
Note: Credit will be given only if all correct choices and no incorrect choices are selected.
Standard Text: Select all that apply.
1. Hemophilia A is diagnosed in men and women in equal numbers.
2. The daughters produced by this union will be carriers of the disorder.
3. The sons of this union will have hemophilia A.
4. The daughters of this union will have a 50% chance of passing hemophilia A on to their daughters.
5. None of the children of this union will manifest hemophilia A.
2,5
Rationale 1: Hemophilia A is diagnosed almost exclusively in men.
Rationale 2: The father will contribute his lone X chromosome to his daughters. Because hemophilia is an X-linked disorder, that X must be affected. Daughters will be carriers of the disease.
Rationale 3: Hemophilia A is an X-linked disorder. The father contributes a Y chromosome to his sons, so there is no direct transfer of the disorder.
Rationale 4: The daughters of this union will have a 50% chance of passing this disorder to their sons.
Rationale 5: Hemophilia affects males. The father cannot pass his affected X chromosome to sons, so they will not be affected.
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