A cell contains the following membrane transporters:
Na+ channel
K+ channel
Na+,K+-ATPase
The resting membrane voltage of the cell is –80 mV and the intracellular and extracellular ion concentrations are:
Intracellular (mEq/L) Extracellular (mEq/L)
Na+ 10 145
K+ 120 4
The cell is treated with a drug to inhibit the Na+,K+-ATPase. What would be the effect of this drug on the following parameters?
Intracellular [Na+] Intracellular [K+] Cell volume Membrane voltage
A. decrease decrease decrease depolarize
B. increase decrease increase depolarize
C. increase increase increase no change
D. decrease increase decrease hyperpolarize
E. increase increase decrease hyperpolarize
ANS: B
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