What explains the observation that mixed lymphocyte reactions carried out between some dizygotic twins have a negligible stimulation index?
What will be an ideal response?
In about 8% of dizygotic twins, the blood circulation is joined and the twins are born chimeric with hematopoietic cells of both twins present in both circulatory systems. A state of tolerance is induced to disparate major and minor histocompatibility antigens, explaining the absence of stimulation in a mixed lymphocyte reaction. These twins would also be expected to be able to donate organs or bone marrow to each other without the development of GVHD or the need for immunosuppressive drugs.
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