During DNA replication, a replication bubble forms but replication forks do not move. This suggests a mutation in the gene coding for___?
a. initiator proteins
b. helicase
c. primase
d. DNA ligase
Ans: b. helicase
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The SRY gene is considered pleiotropic because:
What will be an ideal response?
How might a thermophilic bacterium use chromosome structure to protect against heat-induced DNA degradation?
A) It expresses excess amounts of SMC proteins that allow the DNA to more tightly condense during periods of high heat. B) It can express a specialized topoisomerase that induces negative supercoiling, which provides additional chromosomal stability. C) It expresses a specialized topoisomerase that induces positive supercoiling, which provides additional chromosomal stability. D) It expresses enzymes that inhibit topoisomerase during high heat, which prevents DNA from unwinding and becoming susceptible to heat degradation. E) It expresses helicase, an enzyme that nicks the DNA helix and allows it to assume a more stable conformation and thus to resist heat-induced degradation.
Two 6-base sequences are present in bacterial promoters: TATAAT (located 10 nt upstream from the start site) and TTGACA (located 35 nt upstream from the start site). What is the significance of the fact that these two base sequences are different?
A. Both the location of the start site and the direction of transcription can be established. B. It allows RNA polymerase to distinguish between the template strand and the coding strand of the DNA molecule. C. Binding sites for both the core polymerase and holoenzyme are provided. D. Binding sites for both the holoenzyme and ATP are provided. E. The transcription bubble can be properly formed.
Genes not found on the sex chromosomes will be found on:
A) autosomes. B) Y chromosomes. C) centrosomes. D) X chromosomes.