The patient receiving an intravenous (IV) infusion of morphine sulphate begins to experience respiratory depression and decreased urine output. How is this effect described?
a. Therapeutic
b. Toxic
c. Idiosyncratic
d. Allergic
B
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A The therapeutic effect is the expected or predictable physiological response a medication causes. Respiratory depression and decreased urine output are not the desired (i.e., therapeutic) effects of morphine.
B Toxic levels of morphine may cause severe respiratory depression. Toxic effects may develop after prolonged intake of a medication or when a medication accumulates in the blood because of impaired metabolism or excretion. The patient with a decreased urine output is not excreting the morphine.
C An idiosyncratic effect occurs when a medication causes an unpredictable outcome, such as when a patient overreacts or underreacts to a medication. This is not an example of an idiosyncratic effect.
D When a patient experiences an allergic response to a medication, the medication acts as an antigen, triggering the release of antibodies. The patient may experience itching, urticaria, a rash, or in more severe cases, may have difficulty breathing. This patient's response to morphine is not an example of an allergic effect.
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