A nurse is acting as a preceptor to a graduate nurse. They are discussing the differences between various medications. The nurses understand that, in contrast to the barbiturates, the benzodiazepines have which principal mechanism of action?
a. They cannot pass the blood-brain barrier.
b. They have limited central nervous system depression effects.
c. They are not lipid soluble.
d. They have more difficulty affecting the central nervous system.
ANS: B
The ability of benzodiazepines to depress central nervous system function is low. Because of their high lipid solubility, benzodiazepines readily cross the blood-brain barrier to reach sites in the central nervous system.
Benzodiazepines readily cross the blood-brain barrier.
Benzodiazepines are highly lipid soluble.
Benzodiazepines do not have more difficulty affecting the central nervous system than barbiturates do.
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