At one time the uncoupler 2,4-dinitrophenol was used as a weight reducing drug. Its side-effects, including death, resulted in its discontinued use. How could this drug cause weight loss?
A) The uncoupler allows the oxidation of fats from adipose tissue without the production of ATP. This allows the oxidation to proceed continuously and use up the fats.
B) The uncoupler causes ATP to be produced at a much higher rate than normal and this causes weight loss.
C) The uncoupler inhibits the transport of pyruvate into the matrix of the mitochondria. Fats are then degraded to glycerol and subsequently to pyruvate to provide the necessary energy, thereby depleting fat stores.
D) The uncoupler is an allosteric activator of ATP synthase. This increases the rate of translocation of H+ and the oxidation of fuels, including fats.
A) The uncoupler allows the oxidation of fats from adipose tissue without the production of ATP. This allows the oxidation to proceed continuously and use up the fats.
You might also like to view...
The progress of the eukaryotic cell cycle is regulated primarily by what proteins?
A. Cyclins B. Histone proteins C. Condensins D. FtsZ
Which of the following lymphoid organs or tissues has the immunological function of filtering pathogens from the blood?
A. Lymph nodes B. Thymus C. Spleen D. GALT E. Tonsils
________ are proteins associated with clathrin-coated vesicles that are involved in the binding of vesicles to specific receptors.
Fill in the blank(s) with the appropriate word(s).
Phloem and xylem always lie adjacent to each other in plants. Together, they form which of the following plant structures?
a. leaves b. meristems c. vascular bundle d. epidermis