Although monocytes may circulate for only 36 hours, they can survive for months or even years as tissue macrophages. Monocytes found in the liver are called:
a. alveolar macrophages.
b. Kupffer's cells.
c. histiocytes.
d. monokines.
B
Monocytes are the largest of the leukocytes and constitute only 3% to 7% of the WBC differential. Once they migrate from the bloodstream into the tissues, monocytes mature into tissue macrophages, which are powerful phagocytes. In the lung, these tissue macrophages are known as alveolar macrophages; in the liver, they are Kupffer's cells; in connective tissue, they are histiocytes. When activated by antigens, macrophages secrete substances called monokines that act as chemical communicators between the cells involved in the immune response.
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