Explain the direct and indirect contributions of the Na+-K+ pump to the generation of the resting membrane potential

What will be an ideal response?


The Na+-K+ pump transports three Na+ out of the cell for every two K+ it moves into the cell. This results in an unequal distribution of positive charges across the membrane with inside being more negative compared to the outside. The potential difference generated this way is small relative to the overall membrane potential. The majority of the membrane potential results from the passive movements of Na+ and K+ down their concentration gradients. These gradients are established and maintained by the Na+-K+ pump.

Anatomy & Physiology

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