Peripheral demyelination:
A. Typically affects small diameter axons before large diameter axons.
B. Is a characteristic feature of multiple sclerosis.
C. Affects the structure of oligodendrocytes.
D. Typically affects the Schwann cells of large, well-myelinated axons.
E. Typically affects the axon at the ventral root of the spinal cord.
ANS: D
Rationale: Peripheral neuropathies often involve destruction of the myelin surrounding the largest, most myelinated sensory and motor fibers, resulting in disrupted proprioception (awareness of limb position) and weakness. Guillain-Barré syndrome, metabolic abnormalities, viruses, trauma, and toxic chemicals can cause peripheral demyelination.
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