Mutation of the gene that encodes the factor V, known as the Leiden mutation, results in

A. arterial and venous thrombosis
B. decreased fibrinolysis
C. inactivation of protein C
D. inactivation of protein S
E. inactivation of antithrombin III


A
Leiden mutation makes factor V resistant to inactivation by protein S, which leads to increased arterial and venous thrombosis.

Health & Biomechanics

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