The macrophage secretion that stimulates procollagen synthesis and secretion is:
a. angiogenesis factor.
b. matrix metalloproteinase.
c. vascular endothelial growth factor.
d. transforming growth factor-beta.
ANS: D
Macrophages secrete transforming growth factor-beta to stimulate fibroblasts to secrete the col-lagen precursor procollagen. Angiogenesis factor supports the growth of new vessels. Matrix metalloproteinase remodels proteins at the site of injury. Vascular endothelial growth factors are also involved in vessel growth.
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