Which factors are absolute contraindications for thrombolytic therapy? (Select all that apply.)
a. Active peptic ulcer disease
b. Active internal bleeding
c. Recent head trauma
d. Endocarditis
e. Suspected aortic aneurysm
f. Surgery within the last 10 days
B, C, E
An accurate patient history is essential before giving a thrombolytic drug. Absolute contraindica-tions include active internal bleeding, known allergy to streptokinase products, recent head trau-ma, known bleeding disorders, suspected aortic dissection, increased blood pressure of 200/120 mm Hg, pregnancy or recent delivery, cerebrovascular processes (e.g., recent stroke, recent spinal or cerebral surgery, cranial neoplasm, and prolonged cardiopulmonary resuscitation). Active peptic ulcer disease, endocarditis, and surgery within the past 10 days are relative contraindica-tions for this therapy. The prescriber weighs the pros and cons of the treatment before making a decision to use the drug.
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