What is the initial event in the pathogenesis of idiopathic pulmonary artery hypertension (IPAH)?
a. Insult to the pulmonary endothelium
b. Elevated level of serotonin
c. Monoclonal proliferation of endothelial cells
d. Vascular remodeling
ANS: A
The initial event of IPAH is probably an insult to the pulmonary endothelium (the cells that line the blood vessel).
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