Negative selection of developing B cells ensures that
a. there is not an overabundance of circulating B cells that would compete with other important cell types in the circulation
b. only antigen-activated B cells leave the bone marrow
c. clonal expansion of B cells does not occur in the absence of infection
d. B-cell receptors that bind to normal constituents of the body do not emerge
e. B cells do not leave secondary lymphoid tissues.
D
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