Which of the following are associated with hypercapnic respiratory failure due to respiratory muscle weakness or fatigue?

1. Hyperthyroidism
2. Myasthenia gravis
3. Amyotrophic lateral sclerosis
4. Guillain-Barré syndrome
a. 1 and 3 only
b. 1, 2, and 3 only
c. 3 and 4 only
d. 2, 3, and 4 only


ANS: D
Examples include spinal trauma, motor neuron disease where lesions of the anterior horn cells may gradually lead to progressive ventilatory failure (such as in amyotrophic lateral sclerosis, or poliomyelitis), motor nerve disorders (including Guillain-Barré syndrome and Char-cot-Marie-Tooth disease), disorders of the neuromuscular junction (such myasthenia gravis and botulism), and muscular diseases (including muscular dystrophy, myositis, critical care myopathy, and metabolic disorders).

Health Professions

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