A prescriber is considering pharmacogenetic testing (PGx) for a medication even though no alternative therapy exists. What issues should the nurse discuss with the prescriber?
Note: Credit will be given only if all correct choices and no incorrect choices are selected.
Standard Text: Select all that apply.
1. If the test reveals the client to be a nonresponder, is it ethical to prescribe the medication anyway?
2. If the test inaccurately categorizes the client as a nonresponder and the medication is not prescribed, what are the implications?
3. If the client is sensitive to the drug and will experience adverse effects, should dosing be decreased?
4. If the client is a nonresponder to the medication, should that information be revealed to the client?
5. If the client is prescribed this medication, what follow-up schedule is necessary?
1,2,3,5
Rationale 1: This question is pertinent to the use of PGx testing.
Rationale 2: Testing is not 100% accurate. If the testing is in error and the client does not receive the medication, what are the implications? This is a pertinent consideration.
Rationale 3: This is a pertinent question. If a smaller-than-normal dose is given to prevent adverse effects, will the full effects of the drug on the disease be realized?
Rationale 4: This is not a question that should be considered. It is a given that the client should be a full partner in these decisions and should have accurate information on which to base decisions.
Rationale 5: Results of PGx testing may indicate the need for additional or different follow-up than what is standard.
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