Adenine methylase is an enzyme used during mismatch repair (MMR). It helps determine which strand needs to be repaired by discriminating between template and new DNA strand. If this enzyme is mutated, how would MMR be affected?
A) MMR would be hindered because both strands would be overmethylated and both would appear as template DNA strands and it would not be possible to determine which strand has the mutation.
B) MMR would not be hindered because adenine methylase is not directly involved in MMR.
C) MMR would be hindered because both strands would be unmethylated and both would appear as template DNA strands.
D) MMR would be hindered because both strands would be overmethylated and both would appear as new DNA strands and it would not be able to determine which strand has the error.
E) MMR would be hindered because both strands would be unmethylated and both would appear as new DNA strands and it would not be able to determine which strand has the error.
Answer: E
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