What directs the mitosis and maturation action of progenitor neutrophil cells in the bone marrow?
a. Erythropoietin
b. The number of stem cells
c. The number of mature cells in the peripheral circulation
d. Colony-stimulating cytokines
ANS: D
Colony-stimulating cytokines bind to receptors on progenitor cells to direct them to undergo mitosis and to mature to identifiable neutrophil precursor cells. Erythropoietin is the primary cytokine for red cell development. Neither the number of stem cells nor the number of mature cells in circulation function in this role.
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