During the process of endochondral ossification, chondrocytes in the cartilage model die. Why does this occur?

A. Blood supply to the cartilage is cut off by the developing periosteum.
B. Canaliculi connecting adjacent chondrocyte lacunae fuse.
C. Phagocytic osteoclasts in the new bone engulf and destroy the chondrocytes.
D. The developing bone collar secretes enzymes that destroy the chondrocytes.
E. Nutrients cannot diffuse to the chondrocytes through the calcified matrix.


Answer: E

Anatomy & Physiology

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