Lisa has a rare genetic defect that causes acute sun-sensitivity. Her mother has the defect, but her father does not. All
of Lisa’s siblings, two brothers and a sister, are also affected. All four siblings are married, but none of their spouses has
the mutant gene. Draw a pedigree for this family. Identify and explain the most likely mode of transmission for this
disorder What will be an ideal response?
ANSWER:The
most likely mode of transmission for this disorder is via maternal mitochondria.
Mitochondria carry DNA molecules that encode information for 37 mitochondrial genes.
Mitochondria are transmitted from mothers to all their children through the cytoplasm of the
egg (sperm do not contribute cytoplasm or mitochondria at fertilization). As a result, genetic
disorders caused by mutations in mitochondria are maternally inherited and produce a
distinctive pattern of inheritance. All the children of affected females are affected. Affected
females will transmit the disorder to all their offspring, but affected males cannot transmit the
mutations to any of their children.
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Select the correct sequence (beginning to end) for the multi-step process of gene expression:
a. transcription, gene, mRNA, protein b. RNA, transcription, protein, gene c. RNA, translation, protein d. gene, translation, protein e. gene, transcription, mRNA, translation, protein
Briefly describe how toxic materials like DDT that have low concentrations in the water column affect organisms at distant locations
What will be an ideal response?
During which developmental stage is the human body plan set and organ formation occurs?
a. zygote b. blastocyst c. embryo d. fetus e. infant
A change in a single amino acid can change the structure and function of an entire protein. However, in some cases, there can be gene mutations, which change an amino acid in a protein structure but do not change either the overall shape or function of a protein. In cases like these, which level(s) of protein structure would change?
A. none B. primary, secondary, tertiary, and quaternary C. secondary and tertiary D. primary