Adenoviruses are a frequent cause of acute upper respiratory tract infections in humans. Adenoviruses are nonenveloped and their capsid contains a "fiber" protein that is analogous in function to the spike glycoproteins of HIV. Which of the following would be ACCURATE about an adenovirus that has a mutation in its fiber protein gene?
A. The virus would still cause upper respiratory tract infections in humans but at a slower rate.
B. It would be able to infect humans normally, but would not be able to release new adenoviruses from the human cells.
C. Because it has a defective fiber protein, it will now have a broader host range.
D. It would not be able to cause disease in humans.
E. It would be able to infect humans normally, but would not be able to replicate its genome.
Answer: D
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