A liver transplant client is prescribed azathioprine and allopurinol. The nurse understands that when these two agents are used together:
a. the dose of the allopurinol must be less than half the normal dose.
b. the dose of the azathioprine is reduced to 1/3 to 1/4 the normal dose.
c. both doses are decreased when used simultaneously.
d. there is no interaction between them, so no dose alterations are necessary.
ANS: B
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A Incorrect: The allopurinol dose is based on the uric acid level.
B Correct: The dose of the azathioprine is reduced to 1/3 to 1/4 the normal dose.
C Incorrect: The azathioprine dose is decreased.
D Incorrect: The azathioprine dose is decreased.
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