Which condition will neostigmine be used to treat?
a. OAB
b. UTI
c. Postoperative or postdelivery urinary retention
d. Benign prostatic hypertrophy
ANS: C
Neostigmine is an anticholinesterase agent that binds to cholinesterase, preventing the destruction of acetylcholine. The acetylcholine accumulates at cholinergic synapses, and its effects become prolonged and exaggerated. This produces a general cholinergic response manifested by miosis; increased tone of intestinal, skeletal, and bladder muscles; bradycardia; stimulation of secretions of the salivary and sweat glands; and constriction of the bronchi and ureters. An OAB is treated with anticholinergic agents. Anticholinergic agents with more selective action on the bladder are darifenacin, oxybutynin, solifenacin, tolterodine, and trospium. UTIs are treated with anti-infectives. Benign prostatic hyperplasia-related urinary problems are treated with anticholinergic medications.
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