What are the primary roles of VWF?
a. Mediates platelet adhesion and carrier molecule for factor VIII
b. Mediates platelet aggregation and carrier molecule for factor IX
c. Inhibits excess coagulation and activates protein C
d. Activates plasmin and enhances vitamin K factors
ANS: A
VWF is required for normal platelet adhesion; it is also the carrier protein for factor VIII, protecting it from proteolysis and thus prolonging the in vivo half-life from just a few minutes (in the absence of VWF) to 8 to 12 hours.
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