Why is DNA ligase most active on the lagging strand during DNA replication?
a. The lagging strands contain more short DNA segments than the leading strand, which are joined together by
DNA ligase.
b. The lagging strand is synthesized more slowly, and DNA ligase speeds up the DNA polymerase.
c. The lagging strand synthesizes DNA in the 3' ® 5' direction.
d. The lagging strand requires DNA ligase to couple the RNA primer to the Okazaki fragments.
e. DNA ligase performs the function of RNA primase on the lagging strand.
ANSWER: a
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