Mr. Gregory comes to the doctor with high blood pressure. Tests show that he also has elevated levels of renin in his blood and atherosclerotic plaques that have nearly blocked blood flow through his renal arteries. Mr. Gregory is puzzled. Explain to him how decreased blood flow in his renal arteries could cause renin secretion to increase. Map the pathways through which elevated renin causes
high blood pressure for Mr. Gregory.
What will be an ideal response?
Atherosclerotic plaques block blood flow, which decreases GFR and decreases pressure in the afferent arteriole. These are both stimuli for renin release. Renin secretion starts a cascade that produces angiotensin II, a vasoconstrictor. Vasoconstriction increases blood pressure, and the medullary control center responds to Ag II by also increasing ADH, aldosterone secretion, and thirst, collectively increasing blood pressure even further.
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In bronchopulmonary dysplasia, the lungs of newborns become inflamed and scarred
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