The commonly used Guthrie blood test is performed on newborns to diagnose:
a. Down syndrome.
b. isoimmunization.
c. PKU.
d. congenital hypothyroidism (CH).
ANS: C
The Guthrie blood test is an assay commonly used to diagnosis PKU. The test should be performed after the newborn has received postnatal feedings. Down syndrome is diagnosed through chromosomal analysis. Isoimmunization is detected by analysis of blood for unexpected antibodies. CH is diagnosed by analysis of a filter paper blood spot for thyroxine (T4).
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