Antimicrobial susceptibility testing should be performed when:
a. a single bacterial species grows from any body site.
b. an isolate has a predictable susceptibility profile to therapeutic drugs of choice.
c. reliable standardized methods for testing a clinically significant isolate exist.
d. administering intravenous or oral antibio-tics to treat an infection.
C
AST should be done on clinically significant isolates only. The decision as to what defines clini-cal significant may require consultation between microbiology staff, medical director, supervisor, infectious disease specialist, and attending physician in charge of the patient's care. Also, for isolates that are significant but there are not standardized methods for testing, either information from the literature should be used to guide treatment or testing can be done with a disclaimer that results must be viewed with caution. Note: Reporting susceptibility results for organisms with questionable clinical significance may be incorrectly interpreted by the clinician.
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