Which substance has the lowest rate of crossing renal tubular membranes and would therefore be excreted in the urine?
1. Lipid-soluble drugs
2. Volatile drugs
3. Ionized drugs
4. Non-ionized drugs
3
Rationale 1: Lipid-soluble drugs cross renal tubular membranes easily and return to the circulation.
Rationale 2: Volatile drugs are eliminated through respiration.
Rationale 3: Ionized and water-soluble drugs are less likely to cross renal tubular walls and will therefore be excreted.
Rationale 4: Non-ionized drugs cross the renal tubular membranes easily and return to circulation.
Global Rationale: Ionized and water-soluble drugs are less likely to cross renal tubular walls and will therefore be excreted. Non-ionized and lipid-soluble drugs cross renal tubular membranes easily and return to the circulation. Volatile drugs are eliminated through respiration.
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