Explain the role of exposure to antigens in the development of the immune system in the fetus and in the primary and secondary immune responses in children and adults. How does this compare to the role of innate immunity?

What will be an ideal response?


During development, any lymphocytes bearing receptors that bind to molecules in the fetus are eliminated. Thus
the only lymphocytes that persist at birth are those that failed to bind to anything, that is, those that have never
encountered an antigen. Once the immune system has matured (early in infancy), primary immune responses
develop in response to never-before encountered antigens, and secondary immune responses develop with
subsequent exposures to the same antigens. Innate immunity is, at all times, independent of prior antigen exposure.

Anatomy & Physiology

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