Which precaution is most important to teach in preparation for self-care to a client whose antirejection therapy includes sirolimus (Rapamune)?
A. "Report any weight gain of 5 pounds or more in 1 month to your health care pro-vider."
B. "Avoid drinking grapefruit juice when taking this drug."
C. "Avoid crowds and people who might be ill."
D. "Restrict your intake of table salt."
B
This drug is metabolized by an enzyme system that is enhanced by drinking grapefruit juice or eating grapefruit. When the enzyme level or activity is increased, the sirolimus is metabolized too quickly and the client's risk for rejection increases.
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