An adult male patient with a diagnosis of osteomyelitis will soon begin treatment with gentamicin. Which of the following schedules is most likely to maximize efficacy and minimize nephrotoxicity?
A) Gentamicin 500 mg IV OD at 1200
B) Gentamicin 250 mg PO BID at 07:30 and 19:30
C) Gentamicin 500 mg PO TID at 08:00, 12:00, and 17:00
D) Gentamicin 125 mg IV QID at 06:00, 1200, 18:00, and 24:00
A
Feedback:
The ODA method uses higher doses (e.g., 4 to 7 mg/kg) to produce high initial drug concentrations, with no repeat dosing until the serum concentration is quite low (typically 24 hours later). The rationale for this dosing approach is a potential increase in efficacy with a reduced incidence of nephrotoxicity. Gentamicin is not administered orally.
You might also like to view...
The home health nurse is assisting a family to make modifications in their home to better accommodate their visually impaired great-grandfather who will be living with them
When considering the potential modifications, which will have a positive impact on him? A) Install reflective floors to provide increased lighting to the environment. B) Remove lamp shades to increase lighting. C) Use soft blue, gray, and light green tones. D) Install motion-sensor lights when possible.
A patient tells the nurse that his back has not "bothered" him for months but now that he's in the intensive care unit, his back is "killing" him. The nurse considers which cause of this pain when designing interventions?
1. Lack of mobility due to hospitalization 2. Worsening of the disease process that caused the hospital admission 3. An undiagnosed injury to the back 4. Tolerance to pain medication
A patient receives a traditional low-potency antipsychotic medication. The nurse should assess closely for
a. urinary frequency. b. urinary retention. c. hypertension. d. diarrhea.
A community health nurse working with adolescents recognizes that which characteristic would most likely be displayed by an adolescent who is at increased risk to engage in risk-taking beha-vior?
a. Poor academic performance b. High self-esteem c. Middle-class income d. Involvement in extracurricular activities