A client taking carbamazepine (Tegretol) for seizures has also been started on isotretinoin/13-cis-retinoic acid (Accutane). What is this client at an increased risk for?
1. Seizure activity
2. Cardiovascular disease
3. Hyperglycemia
4. Elevated triglycerides
Correct Answer: 1
Rationale 1: Isotretinoin (Accutane) interacts with carbamazepine (Tegretol), and will decrease the blood levels of the latter if the two are used together, which can lead to increased seizure activity.
Rationale 2: Will have increased risk for cardiovascular disease is incorrect because Accutane alone causes an increased risk of cardiovascular disease because of elevated triglyceride levels.
Rationale 3: Will need to monitor blood glucose levels is incorrect. Using Accutane together with hypoglycemic agents can lead to loss of glycemic control.
Rationale 4: Will have elevated triglycerides is incorrect because Accutane alone causes an increased risk of cardiovascular disease because of elevated triglyceride levels.
Global Rationale: Isotretinoin (Accutane) interacts with carbamazepine (Tegretol), and will decrease the blood levels of the latter if the two are used together, which can lead to increased seizure activity. Will have increased risk for cardiovascular disease is incorrect because Accutane alone causes an increased risk of cardiovascular disease because of elevated triglyceride levels. Will need to monitor blood glucose levels is incorrect. Using Accutane together with hypoglycemic agents can lead to loss of glycemic control. Will have elevated triglycerides is incorrect because Accutane alone causes an increased risk of cardiovascular disease because of elevated triglyceride levels.
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