A 28-year-old woman sees her family physician complaining of easy bruising and menorrhagia. She has a platelet count of 60 x 109/L
All other hematology and routine coagulation tests are normal. She has a platelet-associated immunoglobulin G (IgG) autoantibody in her serum. Which of the following is most likely?
a. Chronic immune thrombocytopenic purpura
b. Thrombotic thrombocytopenic purpura
c. Acute immune thrombocytopenic purpura
d. Hemolytic uremic syndrome
ANS: A
Chronic immune thrombocytopenic purpura is most often seen in women between the ages of 20 and 50 years of age. Patients most often complain of easy bruising, recurrent epistaxis, and menorrhagia. Platelet destruction in chronic immune thrombocytopenic purpura is the result of an IgG autoantibody, with various membrane glycoproteins being the most frequent targets.
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