The pathophysiologic effects of spina bifida are due to:
A) Malformation of the brain and spinal column causing spinal fluid to pool at the base of the spine
B) Failure of one or more neural arches to close within the vertebral column of the neural tube
C) Cystic lesions growing into the dorsal root ganglia
D) Hypertrophy of the primary vesicles, which eventually causes the excess fluid to bulge in weakened structures
Ans: B
Feedback:
The major morphogenic defects of the spinal cord and brain are due to the abnormal formation or closure of the neural tube and surrounding tissues, problems that often result in spina bifida. The health problem is not due to the malformation of the mesoderm, lesions in the dorsal root ganglia, or hypertrophy of the primary vesicles.
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