A client with a UTI is ordered to receive trimethoprim-sulfamethoxazole, also known as co-trimoxazole (Bactrim, Septra). The nurse is aware that Bactrim is a combination of two drugs. What is the purpose of this combination?
a. It decreases the response against disease-producing organisms.
b. The two drugs have an antagonistic drug effect.
c. Trimethoprim prevents bacterial resistance to sulfamethoxazole.
d. It prevents toxic drug effects.
ANS: C
Use of sulfonamides leads to bacterial resistance. The trimethoprim prevents this.
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