Which are (is a) potential result(s) of end-organ damage from chronic hypertension?

a. Carotid stenosis
b. Diabetes mellitus
c. Renal insufficiency
d. Coronary artery disease
e. Isolated systolic hypertension
f. Familial hypercholesterolemia


A, C, D

a. Correct. Carotid stenosis refers to occlusion of the carotid artery from atherosclerotic pla-que and can result from chronic hypertension. Older adults with carotid stenosis are at high risk for strokes owing to the risk of a thromboembolic event from the plaque.
b. Incorrect. Diabetes mellitus (DM) is not a result of end-organ damage from chronic hypertension; however, when it accompanies hypertension, DM accelerates the process of end-organ damage and greatly increases the risk of cardiovascular disease.
c. Correct. Renal dysfunction can occur as a result of chronic hypertension as the intimal lin-ing of the renal arteries is damaged over time. This leads to renal artery stenosis and de-creased renal perfusion.
d. Correct. Coronary artery disease is a common result of chronic hypertension.
e. Incorrect. Isolated systolic hypertension is a common consequence of aging but not a result of end-organ damage.
f. Incorrect. Familial hypercholesterolemia is determined by genetic factors and cannot be caused by end-organ damage.

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