Explain the biochemistry involved in platelet function
What will be an ideal response?
Answer:
Platelets become activated as a result of the subendothelial collagen (a) Flat, discoid shape spiked appearance (b) actin and myosin go from a random arrangement to a parallel arrangement; (c) tubulin forms a circumferential band around the organelle zone to assist in expelling granular contents to the surface of the platelets.
Activated platelets adhere to subendothelial collagen with the help of VWF and GP Ib/IX.
Once adhesion takes place, more platelets are recruited to the site and aggregation begins. Substances needed for platelet aggregation: fibrinogen and GP IIb/IIIa.
Platelets secrete their granular contents and initiate secondary hemostasis.
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