A patient who is started on phenytoin (Dilantin), who is also taking amiodarone (Cordarone), should be assessed for what possible effect?
a. Central nervous system depression and sedation
b. Decrease in effectiveness of phenytoin
c. Respiratory depression
d. Increase in serum phenytoin levels
ANS: D
Elevation of phenytoin serum levels (200% to 300%) is observed over several weeks. The dosage of phenytoin must be gradually reduced based on patient response. The combination of phenytoin and amiodarone does not produce sedation and depression, decrease the effectiveness of either drug, or produce respiratory depression.
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