Which assessment finding would concern the nurse if found in the client receiving darunavir (Prezista)?

Question

1. Nausea and vomiting
2. Constipation
3. Abdominal pain, headache, and rash
4. Complete numbness and tingling around the mouth

Answer 1

Correct Answer: 3
Rationale 1: All antiretrovirals have the potential to cause nausea and vomiting.
Rationale 2: Constipation is not a side effect of the medication.
Rationale 3: Darunavir is a protease inhibitor. The nurse would report signs of fever, abdominal pain, headache, and rash.
Rationale 4: Numbness around the mouth might be reported in NRTIs but it not associated with darunavir.
Global Rationale: Severe rashes are possible, and these call for discontinuation of therapy. Nausea and vomiting are expected adverse effects; constipation and numbness around the mouth are not associated with this drug.